The treatment of excessive daytime sleepiness using modafinil following traumatic brain injury is well-documented. In this article, we review its application to the treatment of sleep disorders, fatigue, or excessive nighttime sleepiness. The authors cover patients suffering from insomnia and brain trauma injuries. In addition, they include the patient who suffers from a traumatic brain injury. They provide case studies of the effectiveness of modafinil.
Treatment of excessive sleepiness during the day
An investigation that was retrospective in nature was conduct to assess Modafinil’s effects on excessive daytime sleepiness after trauma. The study was conduct on patients suffering from injuries to the brain that were traumatic and having problems with consciousness. At the time of weeks four and ten, Modafinil’s effects on sleepiness in the daytime were discovere. Modafinil was well-tolerated and decrease insomnia in both groups. The adverse effects it cause were not too significant.
Patients suffering from TBI generally experience increase demands for sleep, but there are some who experience more sleepiness during the day. An excessive amount of daytime sleepiness is usually call hypersomnia. A new term, pleiosomnia, is being considere to describe an increased demand for sleep during the 24 hours. The issue for patients suffering from TBI can be that they are more likely to underestimate their needs for sleep, and the intensity of sleepiness during the day increases when patients fail to get enough rest.
The negative effects of EDS are all-encompassing and the occurrence of EDS isn’t limit to those suffering from brain injuries that are traumatic. It’s also common for people suffering from epilepsy, Parkinson’s disease, and various other neurological conditions. A thorough history is crucial when trying to determine the cause. Patients may also have other issues besides the excessive insomnia that is link to EDS. However, the benefits of this medication are obvious: it can reduce EDS.
Treatment for insomnia following an injury to the brain that is traumatic
Modafinil’s use as a treatment is a promising treatment to treat fatigue and excess nighttime sleepiness triggered by TBI. In a pilot study, it decrease daytime sleepiness by a significant amount in TBI patients as measured using a scale of fatigue severity. Additionally, it enhanced cognitive performance and reduced fatigue. Furthermore, the study revealed that it improve cognitive function and reduced fatigue. Modalert decreased excessive sleepiness during the daytime following TBI.
The authors have no conflicts of interest. Modafinil has been approvefor use in the treatment of narcolepsy as well as sleep disorders resulting from shift work. It also has evidence from clinical trials for the treatment of fatigue associatewith MS. However, further research is require to confirm its effectiveness in treating these diseases.
An investigation conduct on individuals with brain injuries that were traumatic was discover. It was found that Modalert 200 significantly decreased daytime sleepiness and reduce the risk of depression as well as hyperactivity. The study’s results also demonstrate that the drugs also reduce the symptoms of irritability and arousal.
Treatment of fatigue following trauma to the brain
Modafinil’s use for treating post-TBI fatigue is a well-known treatment option. Two trials with 60 participants have offered convincing evidence of its effectiveness. The studies were conduct on healthy subjects as well as patients suffering from TBI. Though they were carried out in diverse groups, The results suggest that modafinil can assist patients suffering from chronic or severe post-TBI fatigue.
This is a second phase single-center study. The participants were assigne modafinil 200 mg or a similar number of placebo tablets. The result was assess using an Epworth Sleepiness Scale and fatigue severity scale. Participants also took a survey on their symptoms. The study concluded that the treatment can enhance cognitive performance among TBI patients.
The study employed an equivalent bioequivalent of modafinil or armodafinil. Modafinil has been approve by the FDA to treat excessive sleepiness during the day as well as shift work sleep disorders and Narcolepsy. It can also be use to treat certain types of fatigue relate to MS. Alongside its effectiveness it has also been test in a variety of other research studies.
